inhibits the growth of bacteria causing respiratory infections @

One pharmaceutical preparation of exogenous lung surfactant, SURFACEN, was tested in vitro on growth of pathogens involved in lung disease. SURFACEN at concentration of 1, 10 and 20 mg/mL was incubated with Streptococcus pneumoniae, Streptococcus agalactiae, Staphylococcus aureus, Klebsiella pneumoniae and Escherichia coli in saline solution by 5 h at 37 °C. In the presence of SURFACEN it was observed a decrease of colony forming units in all evaluated concentrations and from 10 mg/mL a reduction of one logarithm of bacterial growth in all types of bacteria tested was observed. SURFACEN showing antibacterial effect on grampositive and gramnegative bacteria causing lung disease.